John Stones limped out of England’s Nations League game in opposition to Germany at Wembley.
The Manchester City defender appeared to injure his hamstring and was changed in the 37th minute by club team-mate Kyle Walker.
Walker, who has just returned from a muscle damage, started England’s 1- defeat to Italy on Friday.
City host neighbours Manchester United in the Premier League on Sunday, 14:00 BST.
Both of those Stones and Walker have viewed the begin to their season disrupted by injury.
Stones missed City’s Champions League victory at Sevilla while right-back Walker suffered a difficulty in the Premier League draw at Aston Villa at the start off of September.
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